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The role of metrology in nucleic acid testing, many people do not know

The role of metrology in nucleic acid testing, many people do not know

(Summary description)Delta variant is currently the main cause of the global COVID-19 epidemic strain. Relevant scientific research and epidemic prevention and control practices at home and abroad have shown that the delta variant has not caused subversive changes in the biological characteristics of the new coronavirus, and the source of infection and transmission route are basically clear. efficient.

The role of metrology in nucleic acid testing, many people do not know

(Summary description)Delta variant is currently the main cause of the global COVID-19 epidemic strain. Relevant scientific research and epidemic prevention and control practices at home and abroad have shown that the delta variant has not caused subversive changes in the biological characteristics of the new coronavirus, and the source of infection and transmission route are basically clear. efficient.

Information

Delta variant is currently the main cause of the global COVID-19 epidemic strain. Relevant scientific research and epidemic prevention and control practices at home and abroad have shown that the delta variant has not caused subversive changes in the biological characteristics of the new coronavirus, and the source of infection and transmission route are basically clear. efficient.

In relevant scientific research and epidemic prevention and control practice at home and abroad, metrology plays a role&ldquo ;The role of the golden key”.

Below, the metrology experts from the National Biotechnology and Drug Industry Metrology and Testing Center will lead you to understand:

What is biometrics?

What is a reference material?

The role of reference materials in the detection of new coronavirus;

How the reference material ensures the accuracy of the hospital's test results.

In recent years, the "Precision Medicine Plan" has been proposed, its core is "accuracy", and the basis is accurate measurement. Measuring provides “rulers””“weights” with various values ​​and precisions for various measurements.

Whether the process parameters in the process of drug R&D and production are accurately implemented and whether the product performance is accurately measured? The difficulties and problems of the standard" need to be solved with advanced measurement and testing technology.

1. What is a reference material?

Reference material (RM) reference material: is a substance or material that has been determined to have one or more sufficiently uniform characteristic values ​​to serve as a “measurement tool in the analytical measurement industry "A simple understanding is the “weight” in the field of biological and chemical analysis and measurement.

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Coronavirus standard material

2. What are the biological characteristic reference materials?

There are monoclonal antibody reference materials, microbial qualitative and quantitative reference materials, recombinant protein drug active ingredient reference materials, nucleic acid quantitative reference materials, etc.

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The process of nucleic acid quantitative reference material in nucleic acid detection

 

3. How do nucleic acid quantitative reference materials play a role in the detection of new crown nucleic acid?

The new coronavirus pseudovirus nucleic acid reference material has the physical structure of the virus and the specific nucleic acid sequence of the new coronavirus, and is guaranteed by genetic modification technology Reliable biological safety and stability of pseudovirus markers, so that the markers can reproduce newThe process of coronavirus nucleic acid detection realizes the quality control of the whole process from viral nucleic acid extraction to nucleic acid quantification, and provides an accurate "biological scale" for the results of new coronavirus nucleic acid diagnosis, thereby effectively reducing the occurrence of "false negatives" probability.

 

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So, measurement runs through the entire industry chain. Whether in design, manufacture or use, various properties, parameters and operating conditions need to be accurately measured for precise analysis and optimization. It can be said that metrology technology transmits the accurate value of the national metrology standard (standard) to the production workshop, throughout every step of the manufacturing process In the engineering measurement of the process, the role of improving quality and efficiency is to create the "gold standard" of precision medicine.

 

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Time of issue:2020-11-20 09:05:16

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